KEGG   Mus musculus (house mouse): 13361
Entry
13361             CDS       T01002                                 
Symbol
Dhfr, 8430436I03Rik
Name
(RefSeq) dihydrofolate reductase
  KO
K00287  dihydrofolate reductase [EC:1.5.1.3]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00670  One carbon pool by folate
mmu00790  Folate biosynthesis
mmu01100  Metabolic pathways
mmu01240  Biosynthesis of cofactors
mmu01523  Antifolate resistance
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    13361 (Dhfr)
   00670 One carbon pool by folate
    13361 (Dhfr)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    13361 (Dhfr)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     13361 (Dhfr)
SSDB
Motif
Pfam: DHFR_1
Other DBs
NCBI-GeneID: 13361
NCBI-ProteinID: NP_034179
MGI: 94890
Ensembl: ENSMUSG00000021707
UniProt: P00375 Q544T5
Structure
Position
13:92491291..92525561
AA seq 187 aa
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
NT seq 564 nt   +upstreamnt  +downstreamnt
atggttcgaccattgaactgcatcgtcgccgtgtcccaaaatatggggattggcaagaac
ggagacctaccctggcctccgctcaggaacgagttcaagtacttccaaagaatgaccaca
acctcttcagtggaaggtaaacagaatctggtgattatgggtaggaaaacctggttctcc
attcctgagaagaatcgacctttaaaggacagaattaatatagttctcagtagagaactc
aaagaaccaccacgaggagctcattttcttgccaaaagtttggatgatgccttaagactt
attgaacaaccggaattggcaagtaaagtagacatggtttggatagtcggaggcagttct
gtttaccaggaagccatgaatcaaccaggccacctcagactctttgtgacaaggatcatg
caggaatttgaaagtgacacgtttttcccagaaattgatttggggaaatataaacttctc
ccagaatacccaggcgtcctctctgaggtccaggaggaaaaaggcatcaagtataagttt
gaagtctacgagaagaaagactaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (5)   
   KEGG MODULE (2)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
3D Structure (6)   
   PDB (6)   
Protein domain (1)   
   Pfam (1)   
All databases (74)   

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